The Pros and Cons of Penile Injections: An Alternative to Oral ED Medications

The Pros and Cons of Penile Injections: An Alternative to Oral ED Medications
Explore the benefits and drawbacks of penile injections as an alternative treatment for erectile dysfunction, including effectiveness, side effects, and comparison to oral medications.

Share This Post

Erectile dysfunction (ED) affects millions of men worldwide and can have significant impacts on their quality of life and relationships.

While oral medications like Viagra and Cialis are popular and effective treatments for many, some men may not respond well to these drugs or may experience side effects. In such cases, penile injections can offer an alternative treatment option.

This article will discuss the pros and cons of penile injections as an alternative to oral ED medications, helping you make an informed decision about whether this treatment is right for you.

Understanding Penile Injections: An In-Depth Look

Penile injections, also referred to as intracavernosal injections, are a treatment option for erectile dysfunction that involves the direct administration of medication into the corpus cavernosum, the sponge-like erectile tissue that forms the bulk of the penis.

The injected medication promotes the relaxation of smooth muscle in the blood vessels and erectile tissue, leading to increased blood flow into the penis and the subsequent formation of an erection.

There are several medications utilized for penile injections, with the most common being alprostadil, a synthetic version of prostaglandin E1. Alprostadil can be used alone or in combination with other medications, such as papaverine and phentolamine, to form a compounded solution known as “bimix” (two medications) or “trimix” (three medications).

These compounded solutions have been found to be highly effective in treating erectile dysfunction, especially in cases where oral medications have been unsuccessful or contraindicated.

When using penile injections, the medication is typically injected into the side of the penis using a small needle. The process may seem daunting at first, but with proper training from a healthcare provider, most men can become proficient in self-administration. The frequency of injections should be determined by a healthcare provider and should not exceed three times per week, with at least 24 hours between injections1.

It is crucial to use penile injections with the guidance of a healthcare provider, as incorrect administration or improper dosing can lead to complications such as prolonged erections (priapism), pain, and even penile damage.

Monitoring and adjusting the dose under the supervision of a medical professional can help minimize these risks and ensure the safe and effective use of penile injections as a treatment for erectile dysfunction.

YouTube player
video of injections for erectile dysfunction

Pros of Penile Injections


Do penile injections work? Penile injections are considered an effective treatment option for men with erectile dysfunction, with success rates of up to 90%.

Many men who have not responded well to oral medications find success with penile injections.


Penile injections generally work within 5-20 minutes after administration, resulting in a quicker onset of action compared to oral medications, which typically take 30 minutes to an hour to work.

Customizable Dosage

The dosage of penile injections can be tailored to the individual’s needs, allowing for greater control over the strength and duration of the erection.

This is especially beneficial for men who require different dosages based on the specific situation or level of stimulation.

Less Interaction with Food and Alcohol

Unlike oral medications, penile injections are not affected by the consumption of food or alcohol, allowing for greater flexibility in their use.

Cons of Penile Injections


One of the main drawbacks of penile injections is the need for self-administration, which can be intimidating and uncomfortable for some men.

However, with proper training and practice, most men can learn to administer the injections effectively and with minimal discomfort.

Side Effects

Some men may experience side effects from penile injections, including pain, bruising, bleeding, or scarring at the injection site.

In rare cases, priapism (a prolonged and painful erection) may occur, requiring immediate medical attention.

Penile injections cost and Availability

Penile injections can be more expensive than oral medications, depending on the specific medication used and the required dosage.

Additionally, not all pharmacies carry the medications used for penile injections, which may require special ordering.

Comparing Penile Injections to Oral ED Medications

When considering penile injections as an alternative to oral ED medications, it’s essential to weigh the pros and cons and consult with a healthcare professional.

While penile injections can be more effective for some men, the need for self-administration and the potential for side effects may make oral medications a more suitable option for others.

Frequently Asked Questions

Are penile injections safe for everyone?

While penile injections are generally considered safe for most men, certain individuals should not use this treatment. Men with bleeding disorders, a history of priapism, or penile abnormalities (such as Peyronie’s disease) should consult with their healthcare provider before considering penile injections.

How long do the effects of penile injections last?

The duration of the erection achieved with penile injections can vary depending on the medication used and the dosage. In general, erections can last anywhere from 30 minutes to several hours. It’s important to follow the recommended dosage guidelines provided by your healthcare provider to minimize the risk of priapism.

Can penile injections be used in combination with oral ED medications?

It is not recommended to use penile injections in combination with oral ED medications, as this may increase the risk of side effects and priapism. If you’re considering penile injections as an alternative treatment, consult with your healthcare provider to determine the best course of action.


In conclusion, penile injections can be an effective alternative to oral ED medications for some men. By weighing the pros and cons and consulting with a healthcare professional, you can make an informed decision about whether this treatment option is right for you.

Remember to prioritize your health and well-being when considering any medical treatment, and always follow the guidance of your healthcare provider.

References, Studies and Sources:

We are committed to providing our readers with only trusted resources and science-based studies with regards to medication and health information. 

Disclaimer: This general information is not intended to diagnose any medical condition or to replace your healthcare professional. If you suspect medical problems or need medical help or advice, please talk with your healthcare professional.

Share This Post Discount Club

Get Started for $1.

  • Cheapest cash pay option at your retail pharmacy
  • 1,000s of drugs below $10.00 that can beat your co-pay
  • Start for $1 for your first month. Cancel anytime. 
  • Tell us your meds, we tell you the cheapest options.

Popular Destinations

Recent Articles

Is Testosterone a Controlled Substance

Is Testosterone a Controlled Substance: What You Need to Know

In today’s health-conscious society, it’s not uncommon for individuals to consider various supplements and hormones to maintain or enhance their overall well-being. One such hormone, testosterone, is widely known for its role in men’s health and vitality. But is testosterone a controlled substance? In this article, we’ll explore the answer to this question and delve into the world of testosterone boosters and restrictions.

Read More »
Does Finasteride Lower Testosterone

Does Finasteride Lower Testosterone: Uncovering the Facts

As we delve into the world of hair loss treatments, one of the most frequently asked questions is whether finasteride lowers testosterone levels. Finasteride, a well-known treatment for hair loss, works by targeting the hormone responsible for shrinking hair follicles – dihydrotestosterone (DHT). Naturally, those who use finasteride might wonder how it affects testosterone levels, given the tight association between DHT and testosterone.

Read More »

Share On:

More To Explore

Which Lipid Acts as a Chemical Messenger: Adipose Tissue, Cholesterol, Testosterone, or Beeswax?

Delve into the multifaceted and crucial role of lipids in our bodies. Lipids play diverse roles, including acting as chemical messengers, providing structural support

Is Testosterone a Controlled Substance: What You Need to Know

In today’s health-conscious society, it’s not uncommon for individuals to consider various supplements and hormones to maintain or enhance their overall well-being. One such

Does Finasteride Lower Testosterone: Uncovering the Facts

As we delve into the world of hair loss treatments, one of the most frequently asked questions is whether finasteride lowers testosterone levels. Finasteride,

Does Sex Increase Testosterone? Uncovering the Truth

There’s a common belief that engaging in sexual activity can lead to an increase in testosterone levels. Many people wonder, does sex actually increase

How Long After Neutering Dog Is Testosterone Gone: What Every Dog Owner Needs to Know

Inquiries regarding the duration for testosterone levels to decline after the neutering procedure are common among dog owners. We know that testosterone plays a

Zinc Testosterone: Boosting Your Levels Naturally

The connection between zinc and testosterone has been a topic of discussion in the realm of men’s health for quite some time. A vital

Bioavailable Testosterone: Uncovering the Essential Facts

When discussing testosterone levels, it’s essential to address bioavailable testosterone. This particular component of testosterone plays a vital role in our overall health and

Does Semen Retention Increase Testosterone? Exploring the Connection

Semen retention is a topic that has gained quite a bit of attention in recent years. As an ancient practice that’s found new life

Best Testosterone Booster for Men Over 50: Top Picks and Tips

As men age, maintaining optimal testosterone levels is crucial for overall health and strength. Men over 50 may experience a natural decline in these

GNC Testosterone: Understanding the Benefits and Available Products

Testosterone plays a crucial role in regulating multiple body functions, especially in men. Maintaining optimal testosterone levels can greatly impact overall health, fitness, and

Does Creatine Increase Testosterone: Uncovering the Truth

Does Creatine increase testosterone levels? This question arises because we are well aware of the crucial role that testosterone plays in muscle building and

Does Testosterone Make You Angry? Debunking the Myths

Over time, testosterone has gained quite a reputation for being linked with aggression and anger. However, it’s crucial to understand the nuances behind this

Testosterone Booster Walmart: Our Top Picks and Recommendations

Searching for an effective testosterone booster can be a daunting task, especially with a wide variety of options available on the market. With Walmart

Does Sleeping Naked Increase Testosterone? Debunking the Myth

As we explore the world of sleep optimization, one question often arises: Does sleeping naked increase testosterone? The connection between sleep, clothing, and hormone

Does Testosterone Make You Gain Weight? Uncovering the Facts

Many people wonder does testosterone make you gain weight. It’s a topic that arises quite often, especially as men age and experience fluctuations in

Raw Onion Testosterone: Unlocking Its Natural Potential

In the realm of enhancing testosterone levels, our attention is consistently drawn to natural approaches. The concept of raw onions as a prospective testosterone

Testosterone Cycle: Understanding the Basics for Optimal Results

Embarking on a testosterone cycle can be an effective way to enhance one’s performance, muscle mass, and overall well-being. We’ll dive into the basics

Does Low Testosterone Cause ED: Unraveling the Connection

We often hear about low testosterone and its impact on various aspects of men’s health. Erectile dysfunction (ED) is one such concern that’s frequently

Free Testosterone Calculator: Uncover Your Levels Easily

Regarding the comprehension of testosterone levels, one useful tool we’ve found is a free testosterone calculator. This calculator can provide helpful information to optimize

Vitamin D Testosterone: The Crucial Link for Men’s Health

There’s a strong connection between vitamin D and overall health, and we’re here to explore how it specifically impacts testosterone levels. Often referred to

How Long Does Testosterone Take to Work: Getting the Timing Right

If you’re wondering how long does testosterone take to work, you’ve come to the right place. We’ll provide some insight into this topic, which

Best Mens Multivitamin Testosterone: Boost Your Levels Naturally

As men, we often encounter fluctuations in our energy levels, stamina, and overall health. These fluctuations could be attributed to changes in our body’s

How to Get Prescribed Testosterone: Our Expert Guide

Dealing with low testosterone levels can be frustrating, but getting a prescription for testosterone is often an effective solution. In this article, we’ll guide

Weider Prime Testosterone Support: Boost Your Performance Today

It’s no secret that maintaining healthy testosterone levels is essential for men’s overall well-being and performance. One popular product designed to support testosterone levels

Online Testosterone Prescription: A Concise Guide for Men

Testosterone imbalances can have a range of negative impacts on men’s health and emotions. When it comes to finding solutions, online testosterone prescriptions have

Saw Palmetto Testosterone: Uncovering the Benefits and Limits

Saw Palmetto Testosterone: When searching for natural methods to increase testosterone levels, many people consider saw palmetto. Derived from the Serenoa repens plant found

Testosterone Undecanoate: Unveiling Its Benefits and Uses

If you’ve been researching hormone therapy options, you may have come across testosterone undecanoate. It’s an ester prodrug of testosterone, used in several medical

Testosterone Cypionate Half Life: Crucial Facts for Bodybuilders and Athletes

The article is to be built for a men’s health audience, authored by a men’s health expert, in the U.S. searching out testosterone information

DHEA Testosterone: Unraveling Its Role in Boosting Levels

Delve into the realm of hormones and their impact on our well-being, where DHEA and testosterone emerge as pivotal factors. DHEA, also known as

Free Testosterone Levels pgmL by Age: Understanding the Numbers

Monitoring your free testosterone levels is essential to maintain optimal health as you age. Testosterone, a vital hormone in our bodies, plays a major