Prozac Overdose: Signs, Symptoms, and Precautions

Share This Post

Prozac is a Food and Drug Administration (FDA)-approved, brand name prescription antidepressant drug that is also sold under the generic name fluoxetine or fluoxetine hydrochloride.

Fluoxetine is also sold under the brand name Sarafem. 

Prozac was the first drug that belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs) to be approved by the FDA for common mental health conditions like major depressive disorder, obsessive-compulsive disorder (OCD), bipolar disorder, premenstrual dysphoric disorder (PMDD), panic attacks, bulimia nervosa, and panic disorders. 

While you might not associate antidepressants like Prozac with a risk of drug overdose, it is definitely possible to overdose on the medication when it is taken in a large dose or combined with other medications.

If you or someone you love takes Prozac, be on the lookout for these signs and symptoms of Prozac overdose.

Signs and Symptoms of Prozac Overdose

Most people associate the risk of overdose with illegal drugs or with prescription narcotic medications, but even drugs that are generally safe, including Prozac, can cause an overdose when too much is consumed at once. 

Most people take between 20 mg and 80 mg of Prozac per day, but when taken at significantly higher doses, the medication can cause an overdose on its own. 

Prozac most commonly results in an overdose when it is mixed with other medications, drugs, or alcohol, even when it is taken at the recommended dose.

These other medications include buspirone (Buspar), lithium (Lithobid), sertraline (Zoloft), tramadol, and warfarin. 

However, some medications such as olanzapine are safe to take in conjunction with Prozac. This is why it's important to seek medical advice before starting Prozac and disclose any current drug use to your doctor

If you believe you or someone you know is experiencing a Prozac overdose, call your doctor or a Poison Control Center immediately. 

No matter the reason for a Prozac overdose, the consequences can be serious and potentially life-threatening.

Early signs of a fluoxetine overdose tend to be mild but can quickly escalate. 

Early signs of a Prozac overdose may include abnormalities such as:

  • Headache
  • Blurred vision
  • Tremor
  • Drowsiness
  • High fever
  • Nausea and vomiting

As an overdose develops, symptoms can become more severe and potentially dangerous. 

Signs of a serious Prozac over dosing may include:

  • Stiff muscles
  • Constant, uncontrollable muscle spasms
  • Fast heart rate
  • Trouble breathing
  • Seizures
  • Hallucinations
  • Dilated pupils
  • Mania
  • Coma

While more serious symptoms of Prozac overdose are relatively rare, they can occur, particularly following the intentional ingestion of excess amounts of Prozac. 

Prozac overdose can result in a medical condition called serotonin syndrome. Serotonin syndrome (toxicity) is a serious and potentially life-threatening condition in which the amount of serotonin in the brain and body gets too high. 

Side effects and symptoms of serotonin syndrome include:

  • Nausea
  • Irregular heart beat (tachycardia)
  • Anxiety
  • Changes in blood pressure
  • Loss of appetite
  • Dry mouth
  • Convulsions
  • Vomiting
  • Diarrhea
  • Confusion
  • Stomach cramps
  • Coma 
  • Death

Prozac Overdose Precautions

The best way to avoid an overdose of fluoxetine is to prevent the overdose from occurring in the first place.

The easiest way to do this is by taking your medication only as directed by your doctor, healthcare provider, or psychiatry professional and to never take your medication in larger doses or more frequently than prescribed. 

Prozac should also not be used by patients who do not have a prescription for the medication, as Prozac can cause significantly dangerous drug interactions with certain tricyclic antidepressants, antipsychotics, benzodiazepines, and other prescription and non-prescription drugs. 

Patients are most likely to overdose on Prozac when they take too much of the drug in a short period of time.

However, Prozac overdose can also occur when the medication is taken in smaller amounts but mixed with other drugs.

You should never mix Prozac with medications like phenelzine, a type of monoamine oxidase inhibitor (MAOI) antidepressant; thioridazine, a drug used to prevent psychotic episodes; or pimozide, a medication that is commonly used to treat Tourette’s syndrome. 

Prozac overdose can also occur when the drug is mixed with alcohol. Symptoms of Prozac overdose that may be caused in tandem with alcohol use may include extreme drowsiness, impaired coordination, or trouble breathing.

Summary

You can overdose on Prozac by taking too much of the drug or by mixing the medication with other medications, drugs, or alcohol.

Prozac overdose symptoms can escalate quickly, and early signs often include headache, blurred vision, tremors, drowsiness, high fever, nausea, and vomiting.

Signs of severe Prozac overdose include stiff muscles, uncontrollable muscle spasms, fast heart rate, trouble breathing, and even mania, coma, or death. 

You should also consult a medical professional if you develop worsening suicidal thoughts or symptoms of mental illness while taking Prozac. 

The best way to prevent a Prozac overdose is to use the drug only as directed by your physician and avoid mixing Prozac with any substance that can potentially contribute to an overdose.

Sources: 

https://www.healthline.com/health/can-you-overdose-on-prozac 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2672257/ 

https://www.medicalnewstoday.com/articles/can-you-overdose-on-prozac 

Sesame Care

Find the best price for great doctors and specialists

  • Thousands of doctors and specialists
  • $13,000,000+ saved by patients
  • 95% patient satisfaction
  • 4.3 on TrustPilot
     

Popular Destinations

Health

Medication

Telehealth Reviews

Shop

Pharmacist Membership

About Us

Pharmacy Near Me

Recent Articles

Share On:

Subscribe To Our Newsletter

Get updates and learn from the best

More To Explore

Cerebral Review: Online Depression & Anxiety Treatment

Today, we’re deep diving with a Cerebral review to give you some insider info to help you narrow down your choices.

What are the signs of Depression?

In this article, we will discuss the signs and symptoms of depression as well as some treatment options for this condition.

Can You Use Gabapentin For Anxiety?

While Neurontin is the most common brand name for gabapentin, other forms (such as Horizant and Gralise) may be prescribed depending on the specific

Zoloft and Weight Loss: Everything You Need To Know

When it comes to Zoloft and weight loss, here’s everything you need to know.

What is Zoloft?

If you have been recently diagnosed with depression and are given Zoloft, you may want to know how the medication works, what common side

What is Venlafaxine HCL ER?

Common mental illnesses like major depressive disorder, generalized anxiety disorder, and panic disorder affect millions of Americans every year. While many different treatment options

Using Prozac With Alcohol: What Are the Risks?

Prozac has become perhaps the most well-known antidepressant in the United States since its approval for the treatment of depression in 1986. Since then,

How Long Does Clonazepam Stay in Your System?

Clonazepam is a popular medication that is most commonly associated with treatment for panic disorder, but the medication was originally developed as a treatment

What is Sertraline and What are the Side Effects?

Sertraline is the generic form of Zoloft, a medication that belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs). SSRIs like

Turn On, Tune In, and…. Heal Your Brain? Psychedelics Return as Potential Therapy for Mental Health Disorders

Before they fell out of favor over half a century ago, psychedelic drugs, like psilocybin and LSD, were studied for various psychiatric diseases such

How Long Does Alprazolam Stay in Your System?

Alprazolam is a fast-acting medication, but exactly how long alprazolam stays in your body varies tremendously based on the form of the medication taken,

Paxil vs Zoloft: Differences, Similarities and Which is Better

Paxil and Zoloft are both popular Food and Drug Administration (FDA)-approved antidepressants that are used to treat a wide range of mental health conditions.

A Supplement for Stress? The Science Behind Adaptogens

Stress is part of all our lives. Adaptogens are a group of herbal supplements studied throughout history as a way to improve the body’s

Does Buspirone Cause Weight Gain?

Many antidepressants can cause weight gain as a side effect. Buspirone may cause an altered appetite as a side effect, which can lead to

Duloxetine Withdrawal: Symptoms, Timeline, and Treatment

Duloxetine withdrawal is very common and well documented, affecting nearly half of all patients. Common withdrawal symptoms include dizziness, headaches, and nausea, and symptoms

Cymbalta vs. Prozac: Comparison Guide

Cymbalta and Prozac are commonly prescribed medications to treat mental health conditions such as major depressive disorder. The medications are similarly effective, although one

How Long Does Ativan Stay in Your System?

Ativan is a commonly prescribed prescription drug that is used by millions of Americans for anxiety, insomnia, and seizure disorders. It is the brand

Why is Mental Health Important?

As the saying goes, “There is no health without mental health,” but why is mental health so important? The reality is that although we

BuSpar: What is it? Uses, Costs, Benefits, and Doses

If you’re one of 40 million American adults suffering from an anxiety disorder or experiencing symptoms of anxiety, you might think that your battle

What are Long-Acting Injectable Antipsychotics? 

Long-acting injectable (LAI) antipsychotics have been shown to prevent psychosis relapse in patients with schizophrenia. To combat poor medication adherence, LAIs are a great