Entresto contains a combination of sacubitril and valsartan. Sacubitril is a blood pressure medicine. It works by increasing the levels of certain proteins in the body that can dilate (widen) blood vessels. This helps lower blood pressure by reducing sodium levels.
Valsartan is an angiotensin II receptor blocker (sometimes called an ARB). Valsartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.
Entresto is used in adults with chronic heart failure. This medicine helps lower the risk of needing to be hospitalized when symptoms get worse, and helps lower the risk of death from heart failure.
Entresto is also used to treat heart failure in children who are at least 1 year old.
Entresto is usually given together with other heart medications.
Entresto is used to treat congestive heart failure, which is also known as chronic heart failure. Specifically, Entresto is used to treat a type of heart failure that results from the heart becoming enlarged and too weak to sufficiently pump blood throughout the body. Congestive heart failure causes people who do not pump enough blood to have blood and other fluids back up inside the lungs, abdomen, liver, and lower body, which can be life-threatening.